VITAMIN C CONTENT OF MONKEY TISSUES IN EXPERIMENTAL POLIOMYELITIS
نویسندگان
چکیده
منابع مشابه
Vitamin C Content of Monkey Tissues in Experimental Poliomyelitis
1. The concentrations of reduced ascorbic acid present in the tissues of normal rhesus monkeys are of a magnitude in keeping with the values found for other animal species which are incapable of synthesizing vitamin C. These concentrations are subject to distinct increase by prolonged parenteral administration of ascorbic acid. 2. The amounts of vitamin C present in nervous tissue and the supra...
متن کاملVitamin C in Relation to Experimental Poliomyelitis
In the experiments reported in the present communication it was found that vitamin C, both natural and synthetic preparations, had no effect on the course of experimental poliomyelitis induced by nasal instillation of the virus. The objection cannot be raised that too large an amount of virus was used, since recent studies (3) on the fate of the nasally instilled virus indicated that all but an...
متن کاملVitamin C Therapy and Prophylaxis in Experimental Poliomyelitis
1. A group of 34 monkeys were infected intracerebrally with 0.1 cc. of a 10 per cent virus suspension. Following infection, 9 animals were treated with daily injections of 700 to 100 mg., 16 with 50 to 10 mg. and 9 with 5 mg. of vitamin C for a period of 2 weeks. In the whole group there were 6 animals that survived without showing any evidence of paralysis. 2 of these had received 50 to 10 mg....
متن کاملFurther Observations on Vitamin C Therapy in Experimental Poliomyelitis
1. A group of 181 monkeys were infected intracerebrally with amounts of virus ranging from 0.01 to 0.05 cc. of a 10 per cent virus suspension. At different intervals following infection treatment of these animals was begun with daily injections of 5 to 100 mg. of natural vitamin C for a period of 2 weeks. Of 89 monkeys treated on the 1st or 2nd day of infection 26 (29.2 per cent) survived witho...
متن کاملA Further Contribution to Vitamin C Therapy in Experimental Poliomyelitis
1. Multiple paralytic doses of poliomyelitis virus (RMV strain), when brought together with small amounts of synthetic ascorbic acid in vitro, are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys. 2. Vitamin C administration to monkeys infected intranasally with the RMV strain produces results which differ in accordance with the technique emp...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1937
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.66.4.479